All that remains of the greatest of Macau's churches is its magnificent stone facade and grand staircase. The church was built in 1602 adjoining the Jesuit College of St. Paul's, the first Western college in the Far East where missionaries such as Matteo Ricci and Adam Schall studied Chinese before serving at the Ming Court in Beijing as astronomers and mathematicians. The church, made of taipa and wood, was brilliantly decorated and furnished, according to early travelers. The facade of carved stone was built in 1620-27 by Japanese Christian exiles and local craftsmen under the direction of Italian Jesuit Carlo Spinola.

After the expulsion of the Jesuits, the college was used as an army barracks and in 1835 a fire started in the kitchens and destroyed the college and the body of the church. The surviving facade rised in 4 colonnaded tiers, and is covered with carvings and statues which eloquently illustrate the early days of the Church in Asia. There are statues of the Virgin and saints, symbols of the Garden of Eden and the Crucifixion, angels and the devil, a Chinese dragon and a Japanese chrysanthemum, a Portuguese sailing ship and pious warnings inscribed in Chinese.

After restoration work, lasting from 1990 to 1995, the back side of the Ruins of St. Paul's was turned into a museum. The ruins are regarded as the symbol of Macau and now offer visitors a new site where they can view the remains of the former Church of the Mother of God, visit a Crypt where the relics of the Martyrs of Japan and Vietnam rest, and a museum of Sacred Art where there are exhibits of paintings, sculptures and liturgical objects from churches and monasteries in the City.